منابع مشابه
Oxidative protein folding in bacteria.
Ten years ago it was thought that disulphide bond formation in prokaryotes occurred spontaneously. Now two pathways involved in disulphide bond formation have been well characterized, the oxidative pathway, which is responsible for the formation of disulphides, and the isomerization pathway, which shuffles incorrectly formed disulphides. Disulphide bonds are donated directly to unfolded polypep...
متن کاملMicroreview Oxidative Protein Folding in Bacteria
In eukaryotes, disulphide bond formation and isomerization is catalysed in the endoplasmic reticulum by protein disulphide isomerase (PDI) and related proteins. Although this eukaryotic system has been intensely studied for almost 40 years, many questions remain unanswered. In 1991, it was discovered that disulphide bond formation in the prokaryotic periplasm is also a catalysed process (Bardwe...
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During seed development, endosperm cells of highly productive cereals, including rice, synthesize disulfide-rich proteins in large amounts and deposit them into storage organelles. Disulfide bond formation involves electron transfer and generates H(2)O(2) as a by-product. To ensure proper development and maturation of seeds, the endosperm cells must supply large amounts of oxidizing equivalents...
متن کاملOxidative protein folding in eukaryotes
The endoplasmic reticulum (ER) provides an environment that is highly optimized for oxidative protein folding. Rather than relying on small molecule oxidants like glutathione, it is now clear that disulfide formation is driven by a protein relay involving Ero1, a novel conserved FAD-dependent enzyme, and protein disulfide isomerase (PDI); Ero1 is oxidized by molecular oxygen and in turn acts as...
متن کاملOxidative Protein-Folding Systems in Plant Cells
PLANTS ARE UNIQUE AMONG EUKARYOTES IN HAVING EVOLVED ORGANELLES the protein storage vacuole, protein body, and chloroplast. Disulfide transfer pathways that function in the endoplasmic reticulum (ER) and chloroplasts of plants play critical roles in the development of protein storage organelles and the biogenesis of chloroplasts, respectively. Disulfide bond formation requires the cooperative f...
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ژورنال
عنوان ژورنال: Molecular Microbiology
سال: 2002
ISSN: 0950-382X,1365-2958
DOI: 10.1046/j.1365-2958.2002.02851.x